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Thioctic Acid (Alpha-Lipoic Acid) + Adenosine + Gluconolactone (PHA) alpha-lipoic acid is both water- and fat-soluble, one of the most potent antioxidants available, and can regenerate other antioxidants like vitamins C and E

Adaptation to such conditions is characteristic of cancer cells survival and the underlying processes of resistance to apoptosis and/or efficient ATG induction

Since selenium supplementation in the forms of sodium selenite and SeM was well documented to induce the expressions of seleno-GPxs through their metabolic assimilation into bioavailable selenium (hydrogen selenide), the initial studies focused on exploring selenium supplementation as a strategy to achieve protection against radiation-induced toxicity [38, 66]

According to another embodiment, the composition for use in treating oxidative stress in a subject in need thereof comprises from about 10 wt % to about 50 wt % Silybum marianum (milk thistle) extract (70%-80% silymarin)