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doi: 10.1371/journal.pone.0060443

Nicotine is the addictive substance in the products, but not the harmful ingredient

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Why formulation matters: Many brands still use harsh alkalizing agents, polymers, and artificial sweeteners that cause irritation despite being tobacco-free. How Lone Pouches differs: We use 100% synthetic nicotine, sodium bicarbonate for balanced pH, and plant-based ingredients, no tobacco, plastics, or chemical fillers