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First, its retrospective design limited our ability to establish definitive causality

Above all, people who want to move from smoking to vaping frequently choose this flavour since it accurately captures tobacco flavour

Figure 2 The possible carcinogenic pathways Epigenetic alteration of oral epithelial cells Many studies have shown that tobacco can cause the abnormal expression of p53, GLUT-1, p16, DAPK, MGMT, P13K and other genes in oral epithelium, which is associated with the occurrence of OSCC

In 2006, Iranians smoked 50 billion cigarettes (worth $33.3 million)

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