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The most significant effects of tobacco use on oral health are oral cancers and precancers, increased severity and extent of periodontal diseases, tooth loss and poor wound-healing post-operatively

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However, when alveolar cell lines are treated with cigarette smoke condensate an increase in the hypomethylation of transcriptional enhancer markers located adjacent to cg05575921 was found, 86 suggesting that cg05575921 and other sites in AHRR may be actively involved in the induction of gene regulatory elements

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