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using an EC with an unknown nicotine delivery profile in this trial prevented us from knowing whether participants received enough nicotine to suppress cravings when using either of the nicotine concentrations provided as part of the gradual reduction approach chosen by the program manufacturer

Decades of declining use means that tobacco taxes generally raise less revenue with each passing year

Alpha-Enolase (ENO1), a potential target in novel immunotherapies

Nicotine acts as a stimulant, encouraging users to smoke more and more