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While exact equivalence is complicated, consumer-facing charts often estimate that a lower-strength pouch like 3mg can approximate a fraction of a typical cigarettes absorbed nicotine, whereas a 6mg pouch may align more closely with something between one and two cigarettes in terms of perceived impact

The multivariate models that considered age, BMI, alcohol drinking and ethnicity also showed similarly OR (95% CI) of prevalence of hypertension for former smokers (OR = 1.48, 95%CI:1.012.18)

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From a scientific standpoint, nicotine activates the sympathetic nervous system - the fight or flight response - raising heart rate, stimulating brain activity, and delaying the onset of deep sleep