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It has been shown that when e-cigarettes are run at high voltages the vapor produced contains high enough levels of formaldehyde-containing compounds to drastically increase a person's risk of developing cancer this risk can be up to 15 times higher than that incurred by long-term smoking

But the safest option remains complete cessation of all tobacco and nicotine products

While a study showed aggravated arthritis symptoms in CS exposure only, IQOS and CS exposures affected lymphoid tissue cellularity and proliferation of splenocytes in mice during arthritis development 55