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Nicotine first activates and then decreases the sensitivity of the nicotinic dopamine receptors of the midbrain, and also enhances glutamatergic stimulation, and reduces GABAergic inhibition of these neurons, resulting in prolonged enhanced effects of these neuromediators 41

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Japan Tobacco has reported that after the pre-sale on May 27, the Ploom AURA and EVO have received positive feedback from users, with both products setting a record for the highest sales in JT's history during the trial period

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