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The nictoine withdrawal status may have different effects on the resting state in smokers 55,56,57

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Coculturing nave CD4 + T cells isolated from the spleens of Gpr15 +/+ mice with CSE (0.251%) did not increase IFN- or IL-4 expression, indicating that CSE does not influence their differentiation into Th1 or Th2 cells (Supplementary Fig