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Conducting additional experiments with RPE cells donated by two people without age-related macular degeneration, or AMD, who did not smoke, one person without AMD who smoked, and one person with early AMD, the researchers identified 1,698 genes that either increased or decreased in expression and were shared between dysfunctional human and mouse RPE cells

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Shields explained, So people with higher changes in levels actually inhaled more, and when you look at that, you see an increase in inflammation. Shields said that the question now was how much inflammation was too much