Yu and colleagues (1985) also reported elimination half-lives of PG following multiple large oral doses (20.7 g three times per day, or 41.4 g two times per day) of PG, with terminal half-lives of 3.8 0.8 hours, with relatively large interpatient variability in plasma concentration
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Tobacco products archived in our laboratory from as long ago as 2004 were included, even though alkaloid compounds are reactive and subject to oxidation and other conversion reactions: for this work, inclusion of historical products was advantageous even if the results might only be interpretable as qualitative