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Penetratin-membrane association: W48/R52/W56 shield the peptide from the aqueous phase

Anti-angiogenic therapies are currently in use (see reviewJeganathan, 2011)

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While it is not clear how this translates to the kinetics of cAMP production in cells expressing individual receptors, the divergence in peptide responses across each receptor is consistent with the dynamic conformational differences that were observed structurally for individual AMYRs bound to distinct peptides

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