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GABAergic interneuron origin of schizophrenia pathophysiology

Drug Information Class Third Generation Antipsychotic Neuroscience-based Nomenclature (NbN) Mode of Action: Receptor Partial Agonist and Antagonist Pharmacological Target: Dopamine, serotonin Brand name Abilify Asimtufii Monograph Monograph link Dosing & Administration Available Doses 720 mg/2.4 mL pre-filled syringe 960 mg/3.2 mL pre-filled syringe Therapeutic Dose Range Schizophrenia and Bipolar Disorder: 400 IM (deltoid or gluteal) once monthly Based on clinical and modelling/simulation study data, the starting dose can be administered by following one of three regimens: One injection start from oral aripiprazole or another oral antipsychotic: On the day of treatment initiation, administer one injection of aripiprazole 2-monthly injectable 960 mg and continue concurrent treatment with oral aripiprazole (10 mg to 20 mg) or current oral antipsychotic for 14 days

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The model was evaluated using fit indices of chi-square ratio to the degree of freedom ( 2/df 0.9)

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