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All procedures and the experimental design were approved by the Ethical Committee for Animal Research of the Federal University of Ouro Preto (Protocol n 2015/35), according to the Brazilian Society of Neuroscience and Behaviour and the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals (8th edition, 2011)

The WHO estimates that, without intervention to cut risks, the total number of COPD deaths will increase by 30% over the next ten years

Symptoms can reverse within 10 years