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In the year 2020, cataracts and glaucoma affected over 15 million and 3 million adults aged over 50, respectively, emerging as the predominant causes of blindness on a global scale [2]

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Repeated dosing studies in rats, dogs, and mice for up to 6 weeks across doses from 0.006 mg/kg to 20 mg/kg via multiple routes showed excellent tolerance

These metabolic adaptations help prevent insulin resistance and reduce the risk of T2DM [12]

Immunoblots Cells or tissues were lysed in buffer (150 mM NaCl, 10 mM Tris pH 7.6, 0.1% SDS and 5 mM EDTA) containing protease and phosphatase inhibitors (Thermo Fisher Scientific, 78445)