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Izzo JG, Malhotra U, Wu TT, Ensor J, Babenko IM, Swisher SG , Correa A, Bresalier RS, Hittelman WN, Ajani JA

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Vinca alkaloids (e.g., vincristine, vinblastine, vinorelbine) are antimicrotubule agents derived from the Madagascar periwinkle plant with multiple indications, including malignancies of the hematologic and lymphatic systems as well as solid tumors

Compared to larger peptides, which often struggle with poor bioavailability and proteolytic degradation, tripeptides offer a balance of functional stability and conformational flexibility

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