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Other factors include, but are not limited to: 1 Age nicotine clearance decreases with age Sex studies have found women metabolize nicotine and cotinine faster than men Estrogen hormones there is a strong relationship between high estrogen levels, observed in premenopausal women, and increased metabolism of nicotine Smoking tobacco itself can also impact how long nicotine stays in your system

Atlanta, GA: Centers for Disease Control and Prevention

This is an important point

according to a report by the Ministry of Health, there were over a million vaping device users that year

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