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In 2012, Kentucky produced 74 percent of the US burley tobacco crop.[21] Burley tobacco is harvested by the stalk, and the harvest is done primarily by hand in a difficult, labor-intensive process

provides tobacco and nicotine products to consumers in the United States, Europe, Latin America, Canada, the Asia-Pacific, the Middle East, Central Asia, Caucasus, and Africa

[12] [45] In eastern Indonesia, leaves from other Piper species are sometimes used in place of betel leaves

Nicotine alters brain chemistry, increasing tolerance and driving higher consumption to achieve the same effect