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We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)

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This substance, crack became enormously popular in the mid-1980s due in part to its almost immediate high and that fact that it is inexpensive to produce and buy

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