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Two case reports assessing CBD (oral dosing from 600 mg/day to 1200 mg/day for 24 days) in patients with mania associated with bipolar disorder did not report any symptom improvement during monotherapy phases (although one patient demonstrated some improvement while on concurrent olanzapine and CBD) [72]

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Niacin Side effects A typical side effect of high-dose niacin is the niacin flush, a reaction that can potentially cause a burning, tingling, and itching sensation on the skin

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Chronic sinusitis If your sudden sneezing is accompanied by facial pressure, sinus headaches, thick nasal discharge, or a diminished sense of smell, chronic sinusitis may be to blame