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As such, an effective treatment would be expected to augment striatal synaptic connectivity, protect SN neurons from underlying death inducers, and ideally stimulate the replacement of lost SN neurons from preexisting pools of neural stem cells

Tesamorelin acts upstream through GHRH-based stimulation, while Ipamorelin engages the ghrelin receptor pathway

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doi: 10.1016/j.ejphar.2025.178091 160 XieZ.WangX.LuoX.YanJ.ZhangJ.SunR.et al