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Keywords Breast cancer, E-cigarette, Infiltrated macrophage, Lung metastasis, Tumor crosstalk Introduction Among women in the US, breast cancer (BC) is the most commonly diagnosed malignancy and is the second leading cause of cancer-related death, after lung cancer

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Options include Nicotine Replacement Therapy (NRT) with a patch, gum or inhaler and medications such as Bupropion or Varenicline