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Concurrently, a significant increase in NADH/NAD + ratio ( P = 0.0002) was observed (Figure 6C), suggesting that the observed metabolic disruptions were a result of oxidative stress, potentially as a compensatory mechanism to sustain energy production and redox homeostasis in the absence of GR

BSH Guidelines for the diagnosis and treatment of cobalamin and folate disorders: Treatment of established cobalamin deciency should follow the schedules in the BNF (Grade 1A)

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