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DISCUSSION 1

Thus, according to Ipsen, Italians peculiar relationship with notions of risk produced a smoking culture that was reticent to reform in light of increased scientific, medical, and public awareness of the health hazards posed by cigarette use, culminating in the rise of an antismoking era that lagged behind American and British responses to the public health crisis posed by cigarettes

Earlier studies suggested that carbon monoxide (CO) might be correlated with smoking-induced cardiovascular changes, as in hypoxic hypoxia ( 12 )

The contribution of individual susceptibility to the effect biomarkers studied was unclear, deserving further investigation