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5 Evidence and controversies regarding the GFD in the management of HT-CD comorbidity 5.1 Established value in CD and possible benefit in CD-HT comorbidity For CD, the evidence is clear: a strict lifelong GFD remains the cornerstone of therapy, improves symptoms, lowers serologic activity, and supports mucosal recovery

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The SURMOUNT trials enrolled 2,542 women and demonstrated approximately 20 percent total body weight reduction regardless of reproductive stage

SAPA and SAC were administered orally from day 1 to day 7, and the mouse model of colitis was induced with 2.0% DSS (W/V) for 7 days (from day 1 to day 7)

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