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2.1.2 PINK1/non-parkin-mediated mitophagy Research has also revealed the existence of PINK1/non-Parkin-mediated mitophagy, in which PINK1 directly recruits LC3 adaptor proteins OPTN and NDP52 to mitochondria, thereby activating mitophagy independent of Parkin ( 2.2 LC3 receptor and ubiquitin-independent pathway Some mitochondrial membrane protein receptors have putative LIR motifs that directly bind to LC3