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But oxidation by cytochrome P450 enzymes is one of the most common forms of bioactivation, resulting in toxic drug metabolites that can bind to cellular macromolecules such as proteins, lipids, or DNA, initiating cellular damage, inflammation, or even carcinogenesis

(2) partially blocking of enzyme active sites during the immobilization process, which makes enzyme less accessible to the substrate

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In some embodiments, the otic triglyceride based pharmaceutical formulations have triglycerides in an amount that is sufficient to stabilize the therapeutic agent for injection into the ear