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Cytokines found in the sera and skin of morphea patients in increased concentration include IL-4, IL-6, and IL-8.18 These cytokines (especially IL-4) upregulate TGF-, initiating a cascade of events resulting in increased production of collagen and other extracellular matrix components via induction of connective tissue growth factor, platelet-derived growth factor, and matrix metalloproteinases

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About 4 out of 5 youth who have ever used tobacco started with a flavored product and nearly 90 percent of youth who use e-cigarettes report using flavors

Sandra Navarro is the President of the Sacramento Branch of the California Writers Club and she joins us today, along with the galas keynote speaker, Pulitzer Prize-winning editorial cartoonist Jack Ohman

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