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The case report found no previous occurrence in the literature but offered four hypothetical mechanisms leading to interactions, suggesting careful monitoring with supplementation (Figure 3)

It is important to note that the study was observational, so it cannot prove that vitamin C causes homocysteine levels to lower

Although further studies are still needed to fully understand the different contributions of these molecular actors into the pathophysiology of DS, the hope is that they will lead to a better understanding of the molecular mechanisms underlying the pathology of DS, and thus to the development of more effective therapy that will bring amelioration or prevention of cognitive deficits in people with DS

CIN, Cervical intraepithelial neoplasia

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