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Studies on similar GLP-1 medications suggest a possible effect on addiction-related pathways

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They found that sustained exposure to CC or ENDS caused a severe systemic inflammatory response, with increased activation of the NLRP3 inflammasome in neutrophils and macrophages, and enhanced dendritic cell-dependent activation of Th1 and Th17 cells in the lungs

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Nicotine does the opposite as it will keep you awake by keeping you alert, increasing your heart rate, and elevating your blood pressure