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95% CI, 1.613.6) was found to be the strongest predictor of these skin lesions, hence one might extrapolate that ustekinumab could be a preferred biologic option in current smokers as at least in a subset of patients, smoking may promote inflammatory pathways amenable to ustekinumabs anti-IL-12/IL-23 activity, though this obviously requires further confirmation both from a mechanistic and clinical perspective [29]

The tragedy is that as a result many millions of smokers may not try vaping and carry on smoking instead, continuing to put themselves at serious risk of cancers, respiratory and heart disease, followed by premature death. The study was published amid reports of a new vape tax to be introduced in the Budget next week.

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