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If concomitant use is necessary, consider dosage reduction of Hydrocodone Bitartrate and Acetaminophen Tablets until stable drug effects are achieved

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When combined with the exclusion of patients with either acute or chronic pancreatitis from prior clinical trials, this observation aligns with the caution raised by the American Diabetes Association to avoid use of GLP-1RAs for patients with any history of acute or chronic pancreatitis 27

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