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For ciliated3 cluster, OCLN pathway was dramatically decreased upon ECE or CSE treatment (Fig
DYING FOR A CIGARETTE Celebrities Who Paid The Ultimate Price For Smoking Desi ArnazLung Cancer Lucille BallLung Cancer & Emphysema Peter JenningsLung Cancer Earl Woods(Father of Tiger Woods) Lung Cancer Dana ReeveWife of Christopher ReeveLung Cancer caused bySecondhand smoke.With family friendRobin Williams Frank SinatraHeart Attack & Lung CancerHe was buried With a pack of Camel cigarettes & a bottle of Jack Daniels in his casket Duke Ellington Lung Cancer Why People Use Tobacco Nicotine Addiction Modulator of everyday emotions Loss of Control 3 of 4 smokers find they cannot quit Makes it more difficult for smokeless users Why People Use Tobacco Build up of Tolerance Same effects build up over time, needing more cigarette to maintain the same original effects, which create dependence Social and Psychological Factors Habits are formed via secondary reinforcers triggers which keep the user dependent upon tobacco The Source of Physiologically Active Compounds Particulate phase (small particle compounds) Nicotine, Water Tar (phenol, cresol, benzo pyrene, DDT) Contains 43 chemicals linked to cancer Gaseous phase (gas compounds) carbon monoxide (CO) carbon dioxide, ammonia, hydrogen cyanide, isopyrene, acetone, arsenic Many of these chemicals are considered carcinogens Whats what
Conclusions Based on the available data, it appears that tobacco smoking has a complex and negative impact on multiple immune and metabolic processes as well as on the mechanisms of oxidative stress and apoptosis
