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It was designed with an inverse pyramidal approach (see image to the right), broadly covering the function of the brain, followed by a general discussion of the interaction between the brain and drugs in addiction development, and ending with an in-depth look at nicotine addiction specifically

Because people who identify themselves as American Indian or Alaska Native are sometimes reported as white on death certificates, the figures provided above may underestimate the real number of deaths among American Indians and Alaska Natives

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