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Hydroquinone 2-4%, the gold standard treatment, requires once or twice daily application with direct tyrosinase inhibition

Therefore, targeting ferroptosis is a potential strategy to prevent drug-induced testicular injury and male infertility

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2021 Apr 23;106(5):1410-1426

Among them, persulfidation of a single cysteine in the Kir 6.1 subunits of vascular ATP-sensitive K + channel increases the activity, causing endothelial and smooth muscle cell hyperpolarization and vasorelaxation ( 2 S/HS levels have been related to the severity of Covid-19 disease through the persulfidation and activation of ATP-sensitive channels of leukocytes, which is leading to novel therapeutic interventions ( + channels, cysteine persulfidation causes inactivation