Studies of the mechanisms governing pulmonary C-fiber activation have led to the identification of transient receptor potential (TRP) channels, which act as cellular sensors that respond to a wide variety of airway irritants, physical stimuli, and endogenous ligands
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Herbal cigarettes, nicotine-free options, and low-tar brands are generally considered less harmful than regular tobacco cigarettes
It can develop from several reasons including, genetic influences, dehydration due to low fluid intake, sun exposure, smoking triggering melanin release, underlying medical conditions or hormonal changes (especially during pregnancy) Busi explains
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