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These studies consistently highlight GHK-Cu's broad tissue-remodeling properties in preclinical models

In the case of alcohol the mechanism is well described: ethanol metabolism involving the CYP2E1 enzyme releases free radicals, and these reduce the level of reduced glutathione in the liver (Lieber, Drug Metabolism Reviews 2004, PMID 15554233)

Mandal, P

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As shown in Figure 8, the results from Western blotting showed that GHK-Cu had little effect on LPS-induced phosphorylation of ERK1/2, however, it significantly reduced the phosphorylation of p38 MAPK and JNK1/2 in LPS + 10 g/g GHK-Cu group compared to the LPS group