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A novel cytosolic FADS6 isoform recently characterized contains only the PAPS domain with considerable FAD synthesis activity, which allows survival of affected patients with biallelic FLAD1 frameshift variants [37] .The FADS6 isoform has approximately 70% of the FAD-synthesizing capacity of human FADS2

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PHASE II The goal of the Advanced High-Speed Enabling Technologies topic area is to design and evaluate enabling technologies at the system and subsystem level, as well as advance the state of the art in modeling and simulation, and performance evaluation and prediction tools that aid in robust design