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Description

The shared host-cell adhesion and haem-binding functionality of many NTHi proteins suggests that bacterial haem-utilisation plays an important role in its interplay with host epithelial cells and may provide an adaptive advantage for colonisation in environments with low haem-iron availability ( 4.2 Survivability and virulence in the respiratory tract Continued NTHi survival in the respiratory tract requires a secure source of host-derived haem

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It upregulates the activity and the expression of antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, increasing the conversion of superoxide radicals into less reactive species and decreasing the oxidative stress [18]

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& Gutkind, J

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In order to fight a disease, immune cells release reactive oxygen species (ROS) and cytokines during an infectious process

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