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There are many practical difficulties associated with subjects smoking in the modern neuroscientific laboratory environment, however electronic cigarettes obviate many of these issues, and provide a close simulation of smoking tobacco cigarettes

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Its implied multiple times throughout the series that these two have an almost romantic relationship, though their physical contact is rather limited in the grand scheme of the story, especially considering Himenos death early on during Season 1

A general guideline suggests that 1 ml of e-liquid might deliver nicotine equivalent to about five packs of cigarettes, though this varies based on usage patterns and e-liquid strength