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CPOX is situated in the mitochondrial intermembrane space and is loosely attached to the mitochondrial inner membrane ( CPOX functions as a homodimer with no cofactor (Phillips et al., 2004

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As a parallel to safety, ecological impact, i.e., whether postbiotics disrupt commensal bacterial communities or select for resistant opportunistic taxa, is also prime for agency consideration in approval and clinical application (Prajapati et al., 2023)

This approach markedly increased local drug concentration while minimizing systemic exposure and off-target effects