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Shadel noted that most of the studies on IQOS have been conducted by Philip Morris, and much more research is needed by independent researchers who are not associated with the company to determine the safety of the product

We used random effects meta-analysis, meta-regression and locally weighted regression and smoothing to examine relationships in the data

Other side effects of nicotine use can include: Increased heart rate and blood pressure Narrowing of arteries Potential for heart disease and stroke Insulin resistance leading to Type 2 diabetes Adverse effects on brain development in adolescents Can Nicotine Cause Cancer

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This variant differs from standard cigarettes primarily in its physical size (super slim diameter) and lighter strength profile