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Indeed, several efforts focusing on HCV micro-elimination (i.e., elimination of HCV as a public health threat within a defined population) have provided real-world evidence for HCV treatment as prevention, demonstrating significant reductions in HCV incidence resulting from widespread treatment.[18,19,20] Impact of Opioid Use and HCV Treatment Adherence Multiple studies that have enrolled persons with active or recent injection drug use have shown excellent adherence with DAA-based HCV therapy (Figure 2).[10,21,22,23,24,25] In particular, persons with opioid use disorder who receive opioid agonist maintenance therapy (e.g., methadone, buprenorphine, or buprenorphine-naloxone) during HCV treatment have excellent rates of adherence, treatment completion, and sustained virologic response (SVR) rates, all comparable to results of other study participants.[26,27] HCV Treatment Outcomes with DAA Therapy in PWID The following summarizes several key studies that have analyzed HCV treatment responses with DAA-based therapy in persons who inject drugs or who have previously injected drugs and were receiving opioid agonist therapy