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Statistics To determine the effect of moderators, a mixed-effects model was used, in which the unknown true effect, y i , is given by y i = 0 + 1 x i 1 + + p x i p + u i + e i , where x i p denotes the value of the p th moderator for the i th study, and p denotes the change in the average true effect for a one unit increase in x i p

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This means: 10 long puffs may equal 20-30 short puffs in nicotine delivery Adjusting puff duration helps control intake without changing nicotine strength Deep lung inhales absorb more nicotine than mouth-held vapor How do different nicotine strengths affect puff equivalence

Dosing regimens and specific use information on NRTs is summarized in Table 1

It can turn a little bitter to the bottom of the bowl and it is cigarish as you may expect