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Conclusions and clinical implications Taken together, there is strong evidence from human studies that tobacco cigarette smoke exposure has severe cardiovascular side effects leading to ED, increased oxidative stress, inflammation, and ultimately to increased cardiovascular morbidity and mortality

Nicotine and nonnicotine factors in cigarette addiction

Is Any Amount of Smoking Safe

[24] In late February 2020, a CDC-authored article in the NEJM stated that the VAPI outbreak was "driven by the use of THC-containing products from informal and illicit sources." [25] [24] However, the CDC also stated, "Evidence is not sufficient to rule out the contribution of other chemicals of concern, including chemicals in either THC or non-THC products, in some of the reported EVALI cases." [26] In 2021, analysis of the aerosols from popular vape brands such as Juul and Vuse found "nearly 2,000 chemicals, the vast majority of which are unidentified." [27] [28] The CDC has stated that the THC cutting agent vitamin E acetate is very strongly implicated in VAPI, [29] but evidence was not sufficient to rule out a contribution from other chemicals of concern to VAPI as of January 2020

The findings revealed levels of puberty-related hormones such as testosterone and luteinizing hormone (LH), increased among marijuana smokers