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While the exact cause-and-effect relationship is complex, studies consistently demonstrate that frequent cannabis use during the teen years can lead to more severe psychiatric symptoms and earlier onset of psychotic disorders like schizophrenia, especially in individuals with a genetic predisposition

80,81,82 The most frequently replicated smoking-related differentially methylated CpG sites (probes) are the hypomethylation of: cg03636183 in coagulation factor II (thrombin) receptor-Like 3 ( F2RL3 ) gene

Nighttime is a recurring motif, symbolizing not just the darkness of day but also of one's mind and soul