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It is a vasoactive substance which means it has an effect on blood vessels

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Thrasher JF, Islam F, Barnoya J, Mejia R, Valenzuela MT, Chaloupka FJ

In a study conducted in a double-blind, placebo-controlled, sequential, multiple assignment randomized trial (SMART), patients who didnt respond initially to monotherapy like varenicline or combination therapy with CNRT were later shown to achieve abstinence via increasing the dosage of varenicline or patients who were already on CNRT to either increase the dose or to switch with varenicline ( 106 )

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