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NNMTi-mediated changes to the availability of nicotinamide/nicotinic acid in conjunction with the presence of moderate amounts of Lactobacillus may promote a positive feedback loop further increasing the abundance of Lactobacillus

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In aging research, the compound provides a unique approach to investigating theories of metabolic decline, as NNMT expression increases with age in many tissues, potentially contributing to the NAD+ decline associated with aging processes