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Specifically, exposure to short (five days [86]), medium (eight months [85]), and longer (fifteen months [118]) e-cigarette aerosol diminished endothelial function, accompanied by decreased intravascular nitric oxide bioavailability and elevated oxidative stress [118]

There are few if any attempts, however, to systematically and comprehensively evaluate the landscape of evidence on smoking risk across a diverse range of health outcomes, with most current research focusing on risk or attributable burden of smoking for a specific condition 7,15 , thereby missing the opportunity to provide a comprehensive picture of the health risk experienced by smokers