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The peptide binds a copper ion, a cofactor studied in tissue-signaling research

Cascone T, William Jr WN, Weissferdt A, Leung CH, Federico L, Haymaker C, Bernatchez C Fossella FV, Mott FE, Papadimitrakopoulou V, Byers LA, Lam VK, Godoy M, Carter B, Lee JJ, Vaporciyan A, Gibbons DL, Swisher SG , Heymach JV, Sepesi B

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In spite of this, a bewildering feature of efforts to examine the role of copper in biological processes is the limited data available on the relative distribution of copper between organs, tissues, cell types and sub-cellular compartments in mammals [2, 44, 76,77,78,79,80,81,82,83]

In the present study, cationic CPP was found to be necessary for effective intracellular delivery and senolytic effects (Figure